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CD8 Antibody (C8/144B), Novus Biologicals™
SDP

Catalog No. NBP232836F Shop All R&D Systems Products
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0.1 mg
0.2 mg
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Catalog No. Quantity
NBP232836F 0.02 mg
NBP232836A 0.1 mg
NBP232836B 0.2 mg
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Catalog No. NBP232836F Supplier Novus Biologicals Supplier No. NBP2328360.02MG
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Description

Mouse Monoclonal Antibody has been used in 2 publications

CD8 Monoclonal specifically detects CD8 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen CD8 alpha
Applications Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone C8/144B
Conjugate Unconjugated
Dilution Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 1-2ug/500ug protein lysate, Immunohistochemistry-Paraffin 1-2ug/ml, Immunohistochemistry-Frozen 1-2ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. P01732
Gene Alias CD8, CD8 antigen, alpha polypeptide (p32), CD8a antigen, CD8a molecule, Leu2, Leu2 T-lymphocyte antigen, MAL, OKT8 T-cell antigen, p32, RPA-T8, RPA-T8 antibody flow, RPA-T8 CD8, RPA-T8 Clone, RPA-T8 Flow, T cell co-receptor, T8 T-cell antigen, T-cell antigen Leu2, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2
Gene Symbols CD8A
Host Species Mouse
Immunogen A 13 amino acid peptide from C-terminal cytoplasmic domain of alpha chain of human CD8 molecule.
Molecular Weight of Antigen 32 kDa
Purification Method Protein G purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Phospho Specific, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 925
Test Specificity CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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