CD8 Antibody (C8/468), Allophycocyanin/Cy7, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP234589APCCY7

Catalog No. N234589APC7

Description

CD8 Monoclonal specifically detects CD8 in Human samples. It is validated for Flow Cytometry.

Specifications

• Antigen: CD8
• Classification: Monoclonal
• Conjugate: APC-Cyanine7
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: CD8A
• Immunogen: Human CD8 recombinant protein (Uniprot: P01732 )
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
• Content And Storage: Store at 4°C in the dark. Do not freeze.

• Applications: Flow Cytometry
• Clone: C8/468
• Dilution: Flow Cytometry
• Gene Alias: CD8, CD8a molecule, LEU2, p32
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Research Discipline: Adaptive Immunity, Cytokine Research, Immunology, Immunophenotyping, Innate Immunity, Phospho Specific, Signal Transduction, Stem Cell Markers
• Gene ID (Entrez): 925.0
• Target Species: Human
• Isotype: IgG1 κ