Invitrogen™ CD8/CD28 Antibody Cocktail, FITC, PE

Antibody Cocktail

Supplier:  Invitrogen™ MA112167

Catalog No. 01-670-886

Description

This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).

CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.

Specifications

• Antigen: CD8/CD28
• Classification: Cocktail
• Conjugate: FITC/PE
• Gene: CD28
• Gene Alias: CD28; CD28 antigen; CD28 molecule; CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8A; CD8a molecule; CD8alpha; CD8b; CD8b molecule; CD8B1; CD8beta; LEU2; Leu-2; Leu2 T-lymphocyte antigen; LY3; LYT3; MAL; MGC138290; OKT8 T-cell antigen; p32; P37; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell-specific surface glycoprotein CD28; T-lymphocyte differentiation antigen T8/Leu-2; Tp44
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 925, 926, 940
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid

• Applications: Flow Cytometry
• Clone: 17D8, B-23, B-23
• Formulation: PBS with 0.2% carrier protein and 0.08% sodium azide
• Gene Accession No.: P01732, P10747, P10966
• Gene Symbols: CD28, CD8A, CD8B
• Immunogen: human peripheral blood T lymphocytes and HPB-ALL T-cell line.
• Quantity: 50 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

Safety and Handling

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