CD80 Monoclonal Antibody (OTI8E9), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-4533	100 μL

Catalog No. 50-168-4533 Supplier OriGene Supplier No. TA812361

Description

Mouse Monoclonal Antibody

CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28, and of an inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, and both molecules can also substitute for each other in this process. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes as a consequence of binding to the CD28 and CTLA4 ligands of T cells. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

Specifications

• Antigen: CD80
• Applications: Flow Cytometry, Western Blot
• Classification: Monoclonal
• Clone: OTI8E9
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CD80
• Gene Accession No.: P33681
• Gene Alias: B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
• Gene Symbols: CD80
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 35-242+Mouse Fc of human CD80 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 941
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1