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CDK8 Polyclonal Antibody, Active Motif™
SDP

Catalog No. p-7188424
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Catalog No. Quantity
50-199-3435 10 μL
50-199-3434 100 μL
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Catalog No. 50-199-3435 Supplier Active Motif Supplier No. 61482
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Description

Rabbit Polyclonal Antibody

A family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. The p54/Cdk 8 interacts exclusively with Cyclin C. The Cdk 8 Cyclin C complex activates the kinase. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.

Specifications

Antigen CDK8
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Cdk8
Gene Accession No. P49336, Q8R3L8
Gene Alias Cdk8; CDK8 protein kinase; Cell division protein kinase 8; cyclin dependent kinase 8; Cyclin-dependent kinase 8; K35; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35; RGD1560888; wu:fk95h11
Gene Symbols Cdk8
Host Species Rabbit
Immunogen This antibody was raised against a peptide within the C-terminal region of human CDk8.
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1024, 264064
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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