CDKN2A Monoclonal Antibody (OTI7B10), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-0690	100 μL

Catalog No. 50-168-0690 Supplier OriGene Supplier No. TA805408

Description

Mouse Monoclonal Antibody

In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression.

Specifications

• Antigen: CDKN2A
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: OTI7B10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: CDKN2A
• Gene Accession No.: Q8N726
• Gene Alias: ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
• Gene Symbols: CDKN2A
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human CDKN2A produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1029
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1