Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ CellSensor™ TrkB-NFAT-bla CHO-K1 Cell Line
CellSensor™ TrkB-NFAT-bla CHO-K1 Cell Line
Supplier: Invitrogen™ K1491
Description
Neurotrophins (NGF, BDNF, NT-3, and NT-4) and their transmembrane receptors (TrkA, TrkB, TrkC, and P75NTR) play important roles in the regulation of neuronal and non-neuronal cell proliferation, differentiation, survival, and death. Neurotrophin signaling also mediates higher-order neuronal activities, such as learning, memory, and behavior. Alterations in neurotrophin levels and their receptors have been implicated in neurodegenerative disorders, such as Alzheimer's disease and Huntington's disease, as well as psychiatric disorders. Neurotrophins propagate their signal through activating multiple signaling pathways (e.g., MAPK, PI3K, PKC).BDNF (brain-derived neurotrophic factor) and its receptor TrkB (also known as NTRK2) play a fundamental role in regulating neural development, survival, and synaptic activity and plasticity. TrkB is also a potential anticancer target, since altered signaling through TrkB promotes tumor formation, survival, and metastasis of various cancers (including neuroblastomas, multiple myelomas, and pancreatic ductal adenocarcinomas). Moreover, growing evidence indicates that BDNF and its receptor influences food intake and body weight control.
CellSensor™ TrkB-NFAT-bla CHO-K1 cells contain a beta-lactamase reporter gene under control of the NFAT Response Element that has been stably integrated into CHO-K1 cells along with TrkB. CellSensor™ TrkB-NFAT-bla CHO-K1 cells express beta-lactamase upon stimulation with brain-derived neurotrophic factor (BDNF). This cell line is a clonal population isolated by flow cytometry and has been tested for robust performance by assessing a variety of assay parameters.
Specifications
| CellSensor™ TrkB-NFAT-bla CHO-K1 cells are shipped on dry ice. Store in liquid nitrogen immediately upon receipt, or thaw for immediate use. | |
| TRKB, PKC and calcium pathway | |
| TrkB-NFAT-bla CHO-K1 Cell Line |
| Cell-based beta lactamase reporter gene | |
| 1 vial | |
| CellSensor™ |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
For Research Use Only. Not for use in diagnostic procedures.
Spot an opportunity for improvement?Share a Content Correction