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CENP-B Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993213
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50-199-3213 10 μg
50-199-3212 100 μg
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Catalog No. 50-199-3213 Supplier Active Motif Supplier No. 61184
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Description

Rabbit Polyclonal Antibody

CENPB is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes and is considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Specifications

Antigen CENP-B
Applications Immunocytochemistry, Immunofluorescence
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene CENPB
Gene Accession No. P07199
Gene Alias Cenpb; Cenp-b; CENP-B protein; centromere autoantigen B; Centromere protein B; centromere protein B, 80kDa; Major centromere autoantigen B
Gene Symbols CENPB
Host Species Rabbit
Immunogen This CENP-B antibody was raised against a recombinant protein corresponding to the C-terminal region of human CENP-B.
Purification Method Protein A
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1059
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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