Centromere protein R Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6558	Proteintech Group Inc 107431AP150UL	150 μL

Description

ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Specifications

• Antigen: Centromere protein R
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q13352
• Gene ID (Entrez): 23421
• Immunogen: Centromere protein R Fusion Protein Ag1204
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ITGB3BP

• Concentration: 0.4 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Beta 3 endonexin, CENP R, CENPR, Centromere protein R, HSU37139, ITGB3BP, NRIF3, TAP20
• Gene Symbols: ITGB3BP
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody