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  5. Tocris Bioscience™ Ceritinib

Tocris Bioscience™ Ceritinib
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Catalog No. p-7166815
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3

Ceritinib is a highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC50 values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.

Specifications

Synonym LDK378
Quantity 10 mg
Molecular Formula C28H36ClN5O3S
Formula Weight 558.14
Product Type Inhibitor
Purity 98%
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