Chd5 Monoclonal Antibody (5A10), Active Motif™

Rat Monoclonal Antibody

Supplier:  Active Motif 61684

Catalog No. 50-199-3617

Description

CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.

Specifications

• Antigen: Chd5
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Accession No.: A2A8L1, Q8TDI0
• Gene Symbols: CHD5
• Immunogen: This antibody was raised against a peptide within the C-terminal region of mouse Chd5.
• Quantity: 10 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: 5A10
• Conjugate: Unconjugated
• Gene: CHD5
• Gene Alias: 4930532L22Rik; ATP-dependent helicase CHD5; AW060752; B230399N07Rik; CHD5; CHD-5; chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5; KIAA0444
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 26038, 269610
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid