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Invitrogen™ CHRNA4 Recombinant Rabbit Monoclonal Antibody (1C2H2)
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Catalog No. PIMA537815
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100 μL
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PIMA537815 100 μL
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Catalog No. PIMA537815 Supplier Invitrogen™ Supplier No. MA537815
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: C6, SH-SY5Y, Mouse liver, U-251MG, Mouse brain, Rat testis Immunogen sequence: PEADGQAAGA LASRNTHSAE LPPPDQPSPC KCTCKKEPSS VSPSATVKTR STKAPPPHLP LSPALTRAVE GVQYIADHLK AEDTDFSVKE DWKYVAMVID R.

This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHRNA4
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 1C2H2
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CHRNA4
Gene Accession No. O70174, P09483, P43681
Gene Alias a4 nicotinic receptor; acetylcholine receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; Acra4; Acra-4; alpha4 nAChR; alpha4-nAChR; BFNC; cholinergic receptor; cholinergic receptor nicotinic alpha 4 subunit; cholinergic receptor, nicotinic alpha 4; cholinergic receptor, nicotinic, alpha 4 (neuronal); cholinergic receptor, nicotinic, alpha 4 subunit; cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA 4; Chrna4; EBN; EBN1; ENFL1; NACHR; nAChR alpha 4; NACHRA4; NACRA4; NARAC; neuronal acetylcholine receptor subunit alpha-4; Neuronal nicotinic acetylcholine receptor alpha 4 subunit; neuronal nicotinic acetylcholine receptor alpha-4 subunit
Gene Symbols CHRNA4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ACHA4 (P43681).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1137, 11438, 25590
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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