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Ciliobrevin A

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Supplier:  R&D Systems 4529/25

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Catalog No. 45-292-5


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Description

Description

Ciliobrevin A is a Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
Specifications

Specifications

2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
>98%
C17H9Cl2N3O2
302803-72-1
25 mg
Observed MW: 358.18
Recommendations

Recommendations

Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

SDS
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Documents

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