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Ciliobrevin A, Tocris Bioscience™

Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein

Manufacturer:  Tocris Bioscience 4529/5

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Catalog No. 45-295


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Description

Description

Hedgehog (Hh) pathway antagonist; blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Perturbs primary cilia formation; inhibits cytoplasmic AAA+ ATPase dynein-dependent microtubule gliding and ATPase activity.
Specifications

Specifications

2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
>98%
Observed MW: 358.18
302803-72-1
C17H9Cl2N3O2
5mg
Safety and Handling

Safety and Handling

Recommended Storage : Store at 4°C

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