Selective CAR agonist
Manufacturer: Tocris 3683/10
DescriptionConstitutive androstane receptor (CAR) agonist (EC50 = 49nM). Displays > 100-fold selectivity over PXR receptors and no activity at LXR, ERα, ERβ, PPAR, RAR, FXR, VDR and THR. Induces CAR nuclear translocation and expression of CYP2B6 in hepatocytes in vitro.
- Chemical Name: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
- Formula: C19H12Cl3N3OS
- CAS Number: 338404-52-7
- Solubility: Soluble to 50mM in DMSO and to 5mM in ethanol
- Purity: >98
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