Invitrogen™ CK2 alpha-2 Monoclonal Antibody (1E1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA517062

Catalog No. PIMA517062

Description

MA5-17062 targets CSNK2A2 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Mouse samples. The MA5-17062 immunogen is purified recombinant fragment of human CSNK2A2 (amino acids: 194-350) expressed in E. Coli. MA5-17062 detects CSNK2A2 which has a predicted molecular weight of approximately 41.2kDa.

Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Specifications

• Antigen: CK2 alpha-2
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: O54833, P19784
• Gene Symbols: CSNK2A2
• Immunogen: Purified recombinant fragment of human CSNK2A2 (amino acids: 194-350) expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 13000, 1459, 307641
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 1E1
• Conjugate: Unconjugated
• Gene: CSNK2A2
• Gene Alias: 1110035J23Rik; C77789; casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2 alpha 2; casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'; casein kinase II, alpha 2, polypeptide; CK II alpha'; CK2; CK2A2; CK2alpha'; CSNK2A1; CSNK2A2
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1