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Complement C3c Antibody (10-02A) - BSA Free, Novus Biologicals™
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Catalog No. NB10064339 Shop All R&D Systems Products
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NB10064339 0.05 mg
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Catalog No. NB10064339 Supplier Novus Biologicals Supplier No. NB10064339
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Description

Mouse Monoclonal Antibody

Complement C3c Monoclonal specifically detects Complement C3c in Human samples. It is validated for ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot.

Specifications

Antigen Complement C3c
Applications ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 10-02A
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Accession No. P01024
Gene Alias AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, complement C3, complement component 3, complement component C3, CPAMD1acylation-stimulating protein cleavage product
Gene Symbols C3
Host Species Mouse
Immunogen Human C3 from normal serum, highly purified by chromatography.
Purification Method Protein A purified
Quantity 0.05 mg
Regulatory Status RUO
Research Discipline Immunology, Innate Immunity, Neuronal Cell Markers, Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) 718
Test Specificity NB100-64339 recognizes 135 kDa complement component 3c (C3c), present in blood serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1
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