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Complement C4b/d Antibody (C4D203), Novus Biologicals™
SDP

Catalog No. NBP24479402 Shop All R&D Systems Products
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0.2 mg
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NBP24479402 0.2 mg
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Catalog No. NBP24479402 Supplier Novus Biologicals Supplier No. NBP2447940.2MG

Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in ELISA, Immunofluorescence

Complement C4b/d Monoclonal antibody specifically detects Complement C4b/d in Human samples. It is validated for SDS-Page, Immunofluorescence.

Specifications

Antigen Complement 4d
Applications SDS-Page, Immunofluorescence
Classification Monoclonal
Clone C4D203
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias C4d
Gene Symbols C4A
Host Species Mouse
Immunogen Recombinant human Complement 4d protein
Molecular Weight of Antigen 192 kDa
Purification Method Protein A or G purified
Quantity 0.2 mg
Regulatory Status RUO
Primary or Secondary Primary
Test Specificity This MAb is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellu
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG1
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