Complement C8A/B/G Antibody (056B-373) - BSA Free, Novus Biologicals™

Mouse Monoclonal Antibody has been used in 3 publications

Supplier:  Novus Biologicals NB10064340

Catalog No. NB10064340

Description

Complement C8A/B/G Monoclonal specifically detects Complement C8A/B/G in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Frozen.

Specifications

• Antigen: Complement C8A/B/G
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Dilution: Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
• Gene Alias: complement component 8, alpha polypeptide, complement component C8 alpha chain
• Host Species: Mouse
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Gene ID (Entrez): 731
• Target Species: Human
• Form: Purified

• Applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
• Clone: 056B-373
• Conjugate: Unconjugated
• Gene Accession No.: P07360
• Gene Symbols: C8A
• Immunogen: Purified human C8
• Quantity: 0.05 mg
• Primary or Secondary: Primary
• Test Specificity: This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG1

For Research Use Only