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Complement C8A/B/G Antibody (056B-373) - BSA Free, Novus Biologicals™
SDP

Catalog No. NB10064340 Shop All R&D Systems Products
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NB10064340 0.05 mg
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Catalog No. NB10064340 Supplier Novus Biologicals Supplier No. NB10064340
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Description

Mouse Monoclonal Antibody has been used in 3 publications

Complement C8A/B/G Monoclonal specifically detects Complement C8A/B/G in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Frozen.

Specifications

Antigen Complement C8A/B/G
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone 056B-373
Concentration 1.0 mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500
Gene Accession No. P07360
Gene Alias complement component 8, alpha polypeptide, complement component C8 alpha chain
Gene Symbols C8A
Host Species Mouse
Immunogen Purified human C8
Purification Method Protein A purified
Quantity 0.05 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 731
Test Specificity This antibody recognizes complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyzes the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane. Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1
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