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Complement Factor B Antibody (014III-33.2.4.3) - BSA Free, Novus Biologicals™
SDP

Catalog No. NB10064343 Shop All R&D Systems Products
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NB10064343 0.05 mg
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Catalog No. NB10064343 Supplier Novus Biologicals Supplier No. NB10064343
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Description

Mouse Monoclonal Antibody

Complement Factor B Monoclonal specifically detects Complement Factor B in Human samples. It is validated for ELISA, Flow Cytometry, Functional, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot.

Specifications

Antigen Complement Factor B
Applications ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry, Immunohistochemistry (Frozen), Western Blot
Classification Monoclonal
Clone 014III-33.2.4.3
Concentration 1 mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:100-1:2000, Flow Cytometry 1:10-1:1000, ELISA 1:100-1:2000, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, Functional
Gene Accession No. P00751
Gene Alias BF AHUS4, B-factor, properdin, BFD, C3 proaccelerator, C3 proactivator, C3/C5 convertase, complement factor B, EC 3.4.21, EC 3.4.21.47, FB, FBI12, GBGCFAB, Glycine-rich beta glycoprotein, glycine-rich beta-glycoprotein, H2-Bf, PBF2, Properdin factor B
Gene Symbols CFB
Host Species Mouse
Immunogen Purified human complement factor b
Purification Method Protein A purified
Quantity 0.05 mg
Regulatory Status RUO
Research Discipline Immunology
Primary or Secondary Primary
Gene ID (Entrez) 629
Test Specificity NB100-64343 recognizes the 30kDa Ba fragment of 90kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes. NB100-64343 inhibits the function of factor B and binds both nascent factor B and the Ba cleavage product. Removal of Sodium Azide is recommended prior to use in functional assays.
Target Species Human
Content And Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Form Purified
Isotype IgG1
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