Complement factor B Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6078	Proteintech Group Inc 101701AP150UL	150 μL

Description

This antibody raised against 573-761aa of human complement factor B can recognize complement factor B and Bb fragment.

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5′ end of the gene for complement component 2.

Specifications

• Antigen: Complement factor B
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Format: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Monoclonal or Polyclonal: Polyclonal
• Storage Requirements: -20°C

• Concentration: 0.14 mg/mL
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Type: Antibody