Invitrogen™ COMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5119011	Invitrogen™ PA5119011	200 μL
PIPA5122073	Invitrogen™ PA5122073	20 μL

Description

COMT Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Specifications

• Antigen: COMT
• Content And Storage: -20°C
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Human
• Gene: Comt
• Gene Alias: Catechol O-methyltransferase; catecholamine-O-methyltransferase; catechol-O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; Comt; Comt1; D16Wsu103e; D330014B15Rik; epididymis secretory sperm binding protein Li 98n; HEL-S-98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
• Gene Symbols: Comt
• Primary or Secondary: Primary
• Purification Method: Antigen affinity chromatography

• Concentration: 500 μg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P21964
• Gene ID (Entrez): 1312
• Immunogen: Recombinant protein Catechol-O-Methyltransferase. The antigen corresponds to amino acid range 52-271 of the target protein.
• Product Type: Antibody