Invitrogen™ CSF1R Monoclonal Antibody (CL11653)

Catalog No.	Quantity
PIMA544167	100 μL

Catalog No. PIMA544167 Supplier Invitrogen™ Supplier No. MA544167

Description

Mouse Monoclonal Antibody

The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: NFDVFLQHNN TKLAIPQQSD FHNNRYQKVL TLNLDQVDFQ HAGNYSCVAS NVQGKHSTSM FFRVVESAYL NLSSEQNLIQ EVTVGEGLNL KVMVEAYPGL QGFNWTYLGP FSDHQP Highest antigen sequence indentity to the following orthologs: Mouse - 59%, Rat - 65%.

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

Specifications

• Antigen: CSF1R
• Applications: Immunocytochemistry
• Classification: Monoclonal
• Clone: CL11653
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Csf1r
• Gene Accession No.: P07333
• Gene Alias: AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms
• Gene Symbols: Csf1r
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human CSF1R (Product #RP-102148)
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1436
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov