CTCF Recombinant Rabbit Monoclonal Antibody, AbFlex™, Active Motif™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3800	Active Motif 91286	10 μg
50-199-3799	Active Motif 91285	100 μg

Description

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.

Specifications

• Antigen: CTCF
• Applications: ChIP sequencing (ChIP-seq), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P49711
• Gene ID (Entrez): 10664
• Immunogen: This antibody was raised against a peptide within human CTCF.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: CTCF

• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: 140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Gene Alias: 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; BOS_17095; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
• Gene Symbols: CTCF
• Isotype: IgG
• Purification Method: Protein A
• Product Type: Antibody