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CXCL12 alpha (SDF-1 alpha) Rabbit anti-Mouse, Rat, Polyclonal, eBioscience™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$109.00 - $249.00

Specifications

Antigen CXCL12 alpha (SDF-1 alpha)
Target Species Mouse, Rat
Conjugate Unconjugated
Isotype IgG
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-137-26 Non-distribution product as customer accommodation.
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Invitrogen
14799281
50 μg Each for $109.00
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50-137-27 Non-distribution product as customer accommodation.
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Invitrogen
14799283
200 μg Each for $249.00
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Description

Description

Description: The polyclonal antibody reacts with both mouse and rat SDF-1 alpha. It was was generated using E. coli-expressed N terminal amio acids 20-89 of mouse SDF-1 alpha as an immunogen. SDF-1 alpha (stromal cell-derived factor-1 alpha), also known as pre-B-cell growth-stimulating factor (PBSF), is a 70-amino acid CXC chemokine originally cloned from a bone marrow stromal cell line. Targeted deletion of the SDF-1 gene resulted in defects of B-cell lymphopoiesis and bone marrow myelopoiesis. SDF-1 has been shown to be chemotactic for lymphocytes. In addition, SDF-1 was recently reported to be a ligand for CXCR4 (LESTR/fusin), a co-receptor for HIV-1 entry into T cells. SDF-1 binding to CXCR4 inhibits HIV-1 entry. Applications Reported: This polyclonal has been reported for use in immunoblotting (WB), immunoprecipitation, and immunohistochemistry. Cross-reactivity to SDF-1 alpha of other species has not been determined. Applications Tested: To achieve best results, titrate antibody by dilution for each application as follows: Western Blot 1:1000 Immunoprecipitation 1:300-500 Immunohistochemistry 1:100-500. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.

CXCL12 is a stromal cell-derived alpha chemokine member of the intercrine family. This gene product and its receptor CXCR4 can activate lymphocytes and have been implicated in the metastasis of some cancers such as breast cancer. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

CXCL12 alpha (SDF-1 alpha)
Unconjugated
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Primary
Polyclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
Mouse, Rat
IgG
Polyclonal
Liquid
Antibody
4° C

For Research Use Only.

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