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Cyclin B1 Antibody (CCNB1/1098), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP247893A30 Shop All R&D Systems Products
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NP247893A30 0.1 mL
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Catalog No. NP247893A30 Supplier Novus Biologicals Supplier No. NBP247893AF350
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Description

Mouse Monoclonal Antibody

Cyclin B1 Monoclonal specifically detects Cyclin B1 in Human, Mouse samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

Antigen Cyclin B1
Applications Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone CCNB1/1098
Conjugate Alexa Fluor 350
Dilution Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias CCNB, cyclin B1, G2/mitotic-specific cyclin B1, G2/mitotic-specific cyclin-B1
Gene Symbols CCNB1
Host Species Mouse
Immunogen Recombinant human full-length Cyclin B1 protein (Uniprot: P14635)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Adaptive Immunity, B Cell Development and Differentiation Markers, Cancer, Cell Biology, Cell Cycle and Replication, Cytokine Research, Immunology, Mesenchymal Stem Cell Markers, Mitotic Regulators, Myeloid derived Suppressor Cell, Phospho Specific, Signal Transduction, Stem Cell Lines, Stem Cell Markers, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 891.0
Test Specificity It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
Target Species Human, Mouse
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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