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Cyclin D1 Antibody (CCND1/809), Alexa Fluor™ 532, Novus Biologicals™
SDP

Catalog No. NP247921A32 Shop All R&D Systems Products
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NP247921A32 0.1 mL
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Catalog No. NP247921A32 Supplier Novus Biologicals Supplier No. NBP247921AF532
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Description

Mouse Monoclonal Antibody

Cyclin D1 Monoclonal specifically detects Cyclin D1 in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Cyclin D1
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
Classification Monoclonal
Clone CCND1/809
Conjugate Alexa Fluor 532
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31
Gene Symbols CCND1
Host Species Mouse
Immunogen Recombinant human Cyclin D1 protein (Uniprot: P24385)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cancer, Cell Cycle and Replication, Core ESC Like Genes, mTOR Pathway, Stem Cell Markers, Wnt Signaling Pathway
Primary or Secondary Primary
Gene ID (Entrez) 595.0
Test Specificity Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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