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Cyclin D1 Antibody (DCS-6), Alexa Fluor™ 350, Novus Biologicals™
SDP

Catalog No. NP233138A30 Shop All R&D Systems Products
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NP233138A30 0.1 mL
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Catalog No. NP233138A30 Supplier Novus Biologicals Supplier No. NBP233138AF350
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Description

Mouse Monoclonal Antibody

Cyclin D1 Monoclonal specifically detects Cyclin D1 in Human, Mouse, Rat, Monkey samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen Cyclin D1
Applications ELISA
Classification Monoclonal
Clone DCS-6
Conjugate Alexa Fluor 350
Dilution ELISA
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BCL1D11S287E, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1), G1/S-specific cyclin D1, G1/S-specific cyclin-D1, PRAD1 oncogene, PRAD1B-cell CLL/lymphoma 1, U21B31
Gene Symbols CCND1
Host Species Mouse
Immunogen Human full length recombinant cyclin D1 protein (Uniprot: P24385)
Purification Method Protein A or G purified
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 595
Test Specificity Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Target Species Human, Mouse, Rat, Primate
Content And Storage Store at 4°C in the dark.
Isotype IgG2a κ
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