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  6. Cycloheximide, MP Biomedicals™

Cycloheximide, MP Biomedicals™

Catalog No. MP219452701 Shop All MP Biomedicals, Inc Products
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Description

Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi.

Cycloheximide exhibits somewhat lower activity against bacteria and certain fungi. Control of various molds and fungi in gelatin-based photographic emulsions, photoengraving glues, and other light-sensitive products is suggested.

  • Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death.
  • CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
  • Cycloheximide inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.
  • Cycloheximide is known to induce FAS/FAS Ligand apoptosis, and triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells in addition to a variety of other cell types. Cycloheximide will also delay or inhibit apoptosis induced by other agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 66-81-9
Molecular Formula C15H23NO4
Molecular Weight (g/mol) 281.35
MDL Number MFCD00082346
InChI Key YPHMISFOHDHNIV-QTEFRXOUNA-N
Synonym Acti-Dione, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide, Naramycin A, Actidione, CHX
PubChem CID 6197
ChEBI CHEBI:27641
IUPAC Name 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
SMILES [H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1

Specifications

Physical Form Powder
Melting Point 103°C to 115°C
Quantity 1 g
Formula Weight 281.36g/mol
Grade Cell Culture

Safety and Handling

Recommended Storage Store at +4°C.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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