Cytokeratin 10 Antibody (KRT10/1990R), Alexa Fluor™ 647, Novus Biologicals™

Rabbit Monoclonal Antibody

Supplier:  Novus Biologicals NBP275768AF647

Catalog No. NB009033

Description

Cytokeratin 10 Monoclonal specifically detects Cytokeratin 10 in Human, Mouse samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Cytokeratin 1/10
• Classification: Monoclonal
• Conjugate: Alexa Fluor 647
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: KRT10
• Immunogen: Recombinant human full-length Cytokeratin 10 protein (Uniprot: P13645)
• Quantity: 0.1 mL
• Research Discipline: Cell Biology, Cellular Markers
• Test Specificity: This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
• Content And Storage: Store at 4°C in the dark.

• Applications: Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
• Clone: KRT10/1990R
• Dilution: Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
• Gene Alias: 67 kDa cytokeratin, CK 1, CK 10, CK1, CK10, Cytokeratin 10, Cytokeratin1, Cytokeratin10, EHK 1, EHK1, EPPK, Hair Alpha Protein, K1, k10, Keratin 1, Keratin 1 (epidermolytic hyperkeratosis), Keratin 10, Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), Keratin type I cytoskeletal 10, Keratin Type II Cytoskeletal 1, Keratin1, Keratin10, KPP, KRT 1, Krt 10, KRT1, KRT10, KRT1A, KRTA, NEPPK
• Host Species: Rabbit
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Isotype: IgG