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Cytokeratin 10 Antibody (KRT10/844 + KRT10/1275), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP24327A70 Shop All R&D Systems Products
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NP24327A70 0.1 mL
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Catalog No. NP24327A70 Supplier Novus Biologicals Supplier No. NBP254327AF750
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Description

Mouse Monoclonal Antibody

Cytokeratin 10 Monoclonal specifically detects Cytokeratin 10 in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Cytokeratin 10
Applications Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone KRT10/844 + KRT10/1275
Conjugate Alexa Fluor 750
Dilution Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias BCIE, BIE, CK10, CK-10, cytokeratin 10, Cytokeratin-10, EHK, K10keratosis palmaris et plantaris, keratin 10, Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), keratin, type I cytoskeletal 10, keratin-10, KPP
Gene Symbols KRT10
Host Species Mouse
Immunogen Recombinant human Cytokeratin 10 protein (Uniprot: P13645)
Purification Method Protein A or G purified
Quantity 0.1 mL
Research Discipline Cytoskeleton Markers
Primary or Secondary Primary
Gene ID (Entrez) 3858.0
Test Specificity This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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