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Cytokeratin 6 Antibody (SPM269), DyLight 650, Novus Biologicals™
SDP

Catalog No. NBP234406C Shop All R&D Systems Products
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NBP234406C 0.1 mL
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Catalog No. NBP234406C Supplier Novus Biologicals Supplier No. NBP234406C
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Description

Mouse Monoclonal Antibody

Cytokeratin 6 Monoclonal specifically detects Cytokeratin 6 in Human, Mouse samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen Cytokeratin 6
Applications Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM269
Conjugate DyLight 650
Dilution Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Gene Alias Allergen Hom s 5, CK6A, CK-6A, CK6C, CK6D, CK-6D, cytokeratin 6A, cytokeratin 6C, cytokeratin 6D, Cytokeratin-6A, Cytokeratin-6D, K6A, K6C, K6D, keratin 6A, keratin 6C, keratin 6D, keratin, epidermal type II, K6A, keratin, type II cytoskeletal 6A, Keratin-6A, KRT6C, KRT6D, Type-II keratin Kb6
Gene Symbols KRT6A
Host Species Mouse
Immunogen A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from C-terminus of human keratin 6
Molecular Weight of Antigen 56 kDa
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cytoskeleton Markers, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 3853
Test Specificity This monoclonal antibody recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.
Target Species Human, Mouse
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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