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Cytokeratin, pan Antibody (AE-1/AE-3) - IHC-Prediluted, Novus Biologicals™
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Catalog No. NBP248225 Shop All R&D Systems Products
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NBP248225 7 mL
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Catalog No. NBP248225 Supplier Novus Biologicals Supplier No. NBP248225
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Description

Mouse Monoclonal Antibody

Cytokeratin, pan Monoclonal specifically detects Cytokeratin, pan in Human, Mouse, Rat, Bovine, Canine, Chicken, Monkey, Rabbit, Reptile, Zebrafish samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Specifications

Antigen pan Cytokeratin
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone AE-1/AE-3
Conjugate Unconjugated
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 10 mM PBS with 0.05% BSA with 0.05% Sodium Azide
Gene Symbols KRT1
Host Species Mouse
Immunogen This Cytokeratin, pan Antibody (AE-1/AE-3) was developed against total keratin isolated from human epidermal callus was used as immunogen to generate the pan cytokeratin antibodies AE1 + AE3 (Woodcock-Mitchell, 1982).
Purification Method Protein G purified
Quantity 7 mL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Biology, Cellular Markers, Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 3848
Test Specificity Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Target Species Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit, Reptile, Zebrafish
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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