DACH1 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-5462	Bethyl Laboratories, Inc A303556AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

Dachshund homolog 1 belongs to the DACH/Dachshund family. It is a transcription factor involved in the regulation of organogenesis. DACH1 plays a role in retinal and pituitary precursor cell proliferation.It is reported to be expressed in breast cancer cell lines and to inhibit transforming growth factor-beta (TGF-beta)-induced apoptosis. DACH1 repressed TGF-beta induction of AP-1 and Smad signaling in gene reporter assays and repressed endogenous TGF-beta-responsive genes by microarray analyses. DACH1 participates in the negative regulation of TGF-beta signaling by interacting with NCoR and Smad4. Mouse DACH1 protein was immunolocalized to specific cell types within the developing kidneys, eyes, cochleae, and limb buds.

Specifications

• Antigen: DACH1
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: OTTHUMP00000040839; dachshund homolog 1 (Drosophila) ; DACH1; RP11-512J14.1; DACH; FLJ10138; dachshund homolog 1
• Gene Symbols: DACH1
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody

• Applications: Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: Q9UI36
• Gene ID (Entrez): 1602
• Immunogen: Between 740 and 760
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: DACH1