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Invitrogen™ DCUN1D1 Polyclonal Antibody
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Catalog No. PIPA519284
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100 μg
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PIPA519284 100 μg
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Catalog No. PIPA519284 Supplier Invitrogen™ Supplier No. PA519284
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine and mouse based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen DCUN1D1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene DCUN1D1
Gene Accession No. Q96GG9
Gene Alias DCN1; DCN1, defective in cullin neddylation 1, domain containing 1; DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); DCN1-like protein 1; DCNL1; DCUN1 domain-containing protein 1; Dcun1d1; DCUN1L1; defective in cullin neddylation 1 domain containing 1; defective in cullin neddylation protein 1-like protein 1; pTes3; Rp42; RP42 homolog; SCCRO; SCRO; squamous cell carcinoma related oncogene; squamous cell carcinoma-related oncogene; Tes3; testis derived transcript 3; testis-specific protein 3
Gene Symbols DCUN1D1
Host Species Goat
Immunogen Synthetic peptide sequence (RPQIAGTKSTT) corresponding to the C-terminus amino acids of DCUN1D1 (aa 248-259).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54165
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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