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Dectin-1/CLEC7A Antibody (BD6), DyLight 755, Novus Biologicals™
SDP

Catalog No. NBP121513IR Shop All R&D Systems Products
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NBP121513IR 0.1 mL
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Catalog No. NBP121513IR Supplier Novus Biologicals Supplier No. NBP121513IR
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Description

Mouse Monoclonal Antibody

Dectin-1/CLEC7A Monoclonal specifically detects Dectin-1/CLEC7A in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen Dectin-1/CLEC7A
Applications Flow Cytometry
Classification Monoclonal
Clone BD6
Conjugate DyLight 755
Dilution Flow Cytometry
Gene Accession No. Q9BXN2
Gene Alias Beta-glucan receptor, BGR, CLECSF12DC-associated C-type lectin 1, C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12, C-type lectin domain family 7 member A, C-type lectin domain family 7, member A, C-type lectin superfamily member 12, dectin-1, DECTIN1CANDF4, Dendritic cell-associated C-type lectin 1, dendritic cell-associated C-type lectin-1, hDectin-1, lectin-like receptor 1
Gene Symbols CLEC7A
Host Species Mouse
Immunogen NIH3T3 cells expressing full length Beta-glucan receptor
Purification Method Protein G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Signal Transduction
Primary or Secondary Primary
Gene ID (Entrez) 64581
Test Specificity NBP1-21513 recognizes human Dectin-1, also known as beta-glucan receptor (betaGR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (betaGR-A and betaGR-B) and several minor isoforms. betaGR-A and betaGR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes betaGR-A only.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2b
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