Invitrogen™ Dectin 1 (soluble) Monoclonal Antibody (2A11), FITC

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA516479	Invitrogen™ MA516479	100 μg
PIMA516480	Invitrogen™ MA516480	50 μg

Description

For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Rat anti Mouse Dectin-1 antibody, clone 2A11 recognizes murine beta-glucan receptor, also known as Dectin-1. Rat anti Mouse Dectin-1 antibody, clone 2A11 recognizes murine beta-glucan receptor, also known as Dectin-1.

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

Specifications

• Antigen: Dectin 1 (soluble)
• Concentration: 0.1 mg/mL
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Rat
• Regulatory Status: RUO
• Formulation: PBS with 1% BSA and 0.09% sodium azide
• Gene Accession No.: Q6QLQ4
• Gene ID (Entrez): 56644
• Immunogen: Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
• Product Type: Antibody

• Clone: 2A11
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2b
• Target Species: Mouse
• Gene: Clec7a
• Gene Alias: Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082
• Gene Symbols: Clec7a
• Primary or Secondary: Primary
• Purification Method: Protein G