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Deoxyribonuclease I Polyclonal Antibody, Rockland™
SDP

Rabbit Polyclonal Antibody

$174.73 - $636.24

Specifications

Antigen Deoxyribonuclease I
Concentration 1 mg/mL
Applications ELISA, Immunoprecipitation, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-1037
SDP
Encompass_Preferred
View Documents
Rockland Immunochemicals
20041610100
100 μg
Each for $636.24
Only null left
Add to Cart
 
50-199-1038
SDP
Encompass_Preferred
View Documents
Rockland Immunochemicals
2004161S
25 μL
Each for $174.73
Only null left
Add to Cart
 
Description

Description

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-DEOXYRIBONUCLEASE I is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified Deoxyribonuclease A [Bovine Pancreas]. Cross reactivity against Deoxyribonuclease A from other tissues and species may occur but have not been specifically determined.

Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis. DNase I, a Ca2+/Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, has been implicated to mediate internucleosomal DNA degradation in human cells undergoing apoptosis. DNase I is highly polymorphic, and at least six alleles of DNase I are known. DNase II, the ubiquitously expressed acidic deoxyribonuclease, acts downstream of caspase activation and may also induce DNA digestion during apoptosis. DNase I cleaves DNA to 5'-phosphodinucleotide and 5'-phospho- oligonucleotide end-products, whereas DNase II cleaves DNA to 3'-phosphomononucleotide and 3'-phosphooligonucleotide end-products. The mechanism by which DNase II cuts DNA is similar to DNase I, which produces nicks rather than double-strand cuts. DNase II is usually present in cytoplasm of epithelial cells, but it appears concentrated in the nuclei of lens fibers. In contrast, DNase I is always concentrated in nuclei of epithelial and fiber cells.
Specifications

Specifications

Deoxyribonuclease I
ELISA, Immunoprecipitation, Western Blot
Unconjugated
Rabbit
Bovine
P00639
282217
Deoxyribonuclease A [Bovine Pancreas]
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
DNASE1
1 mg/mL
Polyclonal
Lyophilized
RUO
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
AI788650; Deoxyribonuclease 1; Deoxyribonuclease I; Deoxyribonuclease1; Deoxyribonuclease-1; DeoxyribonucleaseI; DNASE 1; DNase I; DNase I lysosomal; DNase I, lysosomal; DNASE1; DNaseI; DNL 1; Dnl1; Dornase alfa; DRNI; FLJ38093; human urine deoxyribonuclease I
DNASE1
Primary
Antibody
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