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Deoxyribonuclease I Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody
$174.73 - $636.24
Specifications
Antigen | Deoxyribonuclease I |
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Concentration | 1 mg/mL |
Applications | ELISA, Immunoprecipitation, Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-199-1037
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Rockland Immunochemicals
20041610100 |
100 μg |
Each for $636.24
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50-199-1038
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Rockland Immunochemicals
2004161S |
25 μL |
Each for $174.73
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Description
Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Anti-DEOXYRIBONUCLEASE I is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum as well as purified and partially purified Deoxyribonuclease A [Bovine Pancreas]. Cross reactivity against Deoxyribonuclease A from other tissues and species may occur but have not been specifically determined.
Internucleosomal DNA fragmentation following the activation of endonucleases is the common end point of apoptosis. DNase I, a Ca2+/Mg2+-dependent endonuclease ubiquitously expressed in mammalian tissues, has been implicated to mediate internucleosomal DNA degradation in human cells undergoing apoptosis. DNase I is highly polymorphic, and at least six alleles of DNase I are known. DNase II, the ubiquitously expressed acidic deoxyribonuclease, acts downstream of caspase activation and may also induce DNA digestion during apoptosis. DNase I cleaves DNA to 5'-phosphodinucleotide and 5'-phospho- oligonucleotide end-products, whereas DNase II cleaves DNA to 3'-phosphomononucleotide and 3'-phosphooligonucleotide end-products. The mechanism by which DNase II cuts DNA is similar to DNase I, which produces nicks rather than double-strand cuts. DNase II is usually present in cytoplasm of epithelial cells, but it appears concentrated in the nuclei of lens fibers. In contrast, DNase I is always concentrated in nuclei of epithelial and fiber cells.Specifications
Deoxyribonuclease I | |
ELISA, Immunoprecipitation, Western Blot | |
Unconjugated | |
Rabbit | |
Bovine | |
P00639 | |
282217 | |
Deoxyribonuclease A [Bovine Pancreas] | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
DNASE1 |
1 mg/mL | |
Polyclonal | |
Lyophilized | |
RUO | |
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2 | |
AI788650; Deoxyribonuclease 1; Deoxyribonuclease I; Deoxyribonuclease1; Deoxyribonuclease-1; DeoxyribonucleaseI; DNASE 1; DNase I; DNase I lysosomal; DNase I, lysosomal; DNASE1; DNaseI; DNL 1; Dnl1; Dornase alfa; DRNI; FLJ38093; human urine deoxyribonuclease I | |
DNASE1 | |
Primary | |
Antibody |
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