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  5. Tocris Bioscience™ Dimethylenastron

Tocris Bioscience™ Dimethylenastron

Catalog No. p-7110796
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Inhibitor of mitotic motor kinesin Eg5

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC50 values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro. Cytoprotective.

Specifications

Chemical Name or Material 2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone
CAS 863774-58-7
Quantity 10 mg
Target Kinesin Inhibitors
Molecular Formula C16H18N2O2S
Formula Weight 302.39
Purity >99%
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