Invitrogen™ DLAT Polyclonal Antibody

Catalog No.	Quantity
PIPA584563	100 μL

Catalog No. PIPA584563

Supplier: Invitrogen™ PA584563

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LAIGASEDKL VPADNEKGFD VASMMSVTLS CDHRVVDGAV GAQWLAEFRK YLE Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 94%.

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure.

Specifications

• Antigen: DLAT
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: DLAT
• Gene Accession No.: P10515
• Gene Alias: 6332404G05Rik; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; anti DLAT; Dihydrolipoamide; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; dihydrolipoamide S-acetyltransferase; dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial; DLAT; DLTA; E2; E2 component of pyruvate dehydrogenase complex; EC 2.3.1.12; M2 antigen complex 70 kDa subunit; ODP2; PBC; PDC PDC-E2; PDCE2; PDC-E2; pyruvate dehydrogenase complex component E2
• Gene Symbols: DLAT
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human DLAT. Recombinant protein control fragment (Product #RP-105242).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1737
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov