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  8. DMH-1, Tocris Bioscience™ 

DMH-1, Tocris Bioscience™

Catalog Number 412610
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
1206711-16-1
C24H20N4O
380.45
MFCD18384963
JMIFGARJSWXZSH-UHFFFAOYSA-N
dmh-1, dmh1, dmh 1, 4-6-4-propan-2-yloxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl-quinoline, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-propan-2-yl oxy phenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, dmh hplc, quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl
50997747
CHEBI:86289
4-{6-[4-(propan-2-yloxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline
CC(C)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=C2C=CC=CC2=NC=C1
This item is not returnable. View return policy
1206711-16-1
C24H20N4O
380.45
MFCD18384963
JMIFGARJSWXZSH-UHFFFAOYSA-N
dmh-1, dmh1, dmh 1, 4-6-4-propan-2-yloxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl-quinoline, 4-6-4-isopropoxyphenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, 4-6-4-propan-2-yl oxy phenyl pyrazolo 1,5-a pyrimidin-3-yl quinoline, dmh hplc, quinoline, 4-6-4-1-methylethoxy phenyl pyrazolo 1,5-a pyrimidin-3-yl
50997747
CHEBI:86289
4-{6-[4-(propan-2-yloxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl}quinoline
CC(C)OC1=CC=C(C=C1)C1=CN2N=CC(=C2N=C1)C1=C2C=CC=CC2=NC=C1

Description

Selective ALK2 inhibitor

DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC50 = 108 nM or 12.6 nM in in vitro kinase assays). DMH-1 exhibits 6- and 19-fold selectivity for ALK-2 over ALK-1 and ALK-3, respectively, and no significant inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. DMH-1 blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614). DMH-1 suppresses lung cancer cell proliferation, migration, invasion in vitro and reduces tumor growth in a mouse lung cancer xenograft model. DMH-1 inhibits cellular autophagy responses. DMH-1 induces intestinal differentiation in human intestinal organoids (hIOs) derived from human pluripotent stems cells (hPSCs).
Quantity 10 mg
Formula Weight 380.44
Percent Purity >98%
Chemical Name or Material DMH-1

Safety and Handling

Recommended Storage Store at +4°C
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