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DOG1/TMEM16A Antibody (DOG-1.1), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP234606A70 Shop All R&D Systems Products
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NP234606A70 0.1 mL
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Catalog No. NP234606A70 Supplier Novus Biologicals Supplier No. NBP234606AF750
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Description

Mouse Monoclonal Antibody

DOG1/TMEM16A Monoclonal specifically detects DOG1/TMEM16A in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen DOG1/TMEM16A
Applications Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone DOG-1.1
Conjugate Alexa Fluor 750
Dilution Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias ANO1, anoctamin 1, DOG1, ORAOV2, TAOS2, TMEM16A
Gene Symbols ANO1
Host Species Mouse
Immunogen A synthetic peptide from human canine1/TMEM16A protein (aa 904-986), conjugated to a carrier protein. ( (Uniprot: Q5XXA6 )
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 55107
Test Specificity Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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