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DOK6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

$518.60

Specifications

Antigen DOK6
Concentration 0.2 mg/mL
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-172-9216
SDP
Encompass_Preferred
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Proteintech Group Inc
141081AP150UL
150 μL
Each of 1 for $518.60
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Description

Description

DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predomitly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.
Specifications

Specifications

DOK6
Western Blot
Unconjugated
Rabbit
Human, Mouse, Rat
Q2MHE5, Q6PKX4
220164, 498898, 623279
DOK6 Fusion Protein Ag5254
Primary
-20°C
DOK6
0.2 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
docking protein 6, DOK5L, DOK6, HsT3226
Dok6
IgG
Antigen Affinity Chromatography
Antibody
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