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  5. Tocris Bioscience™ Dooku 1

Tocris Bioscience™ Dooku 1
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Catalog No. p-7161617
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ∼1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Specifications

Chemical Name or Material 2-[(2,6-Dichlorobenzyl)thio)-5-(1 H-pyrrol-2-yl)-1,3,4-oxadiazole
CAS 2253744-54-4
Quantity 10 mg
Target Other Piezo Channel Compounds
Molecular Formula C13H9Cl2N3OS
Formula Weight 326.2
Purity 98%
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