Invitrogen™ Doublecortin Monoclonal Antibody (3E1)

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA547314	Invitrogen™ MA547314	500 μL
PIMA547412	Invitrogen™ MA547412	100 μL

Description

Doublecortin Monoclonal Antibody for Western Blot, ICC/IF, IHC

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

Specifications

• Antigen: Doublecortin
• Concentration: 1 mg/mL
• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: O43602, O88809, Q9ESI7
• Gene ID (Entrez): 13193, 1641, 84394
• Immunogen: Recombinant full length human Lis-A isoform of doublecortin expressed in and purified from E. coli.
• Product Type: Antibody

• Clone: 3E1
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2a
• Target Species: Human, Mouse, Rat
• Gene: DCX
• Gene Alias: DBCN; Dbct; DC; Dcn; DCX; doublecortex; doublecortin; doublin; lissencephalin-X; lissencephaly, X-linked (doublecortin); LISX; Lis-X; LIS-XD; Neuronal migration protein doublecortin; OTTHUMP00000023860; OTTHUMP00000216316; SCLH; XLIS
• Gene Symbols: DCX
• Primary or Secondary: Primary
• Purification Method: Purified