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DQP 1105, Tocris Bioscience™

Catalog No. 449150
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

GluN2C/GluN2D-selective NMDA antagonist

Noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Chemical Identifiers

CAS 380560-89-4
Molecular Formula C29H24BrN3O4
Molecular Weight (g/mol) 558.432
InChI Key CADIBCWPGCNUBD-WEMUOSSPSA-N
Synonym 4-5-4-bromophenyl-3-2-hydroxy-6-methyl-4-phenylquinolin-3-yl-4,5-dihydro-1h-pyrazol-1-yl-4-oxobutanoic acid, 4-5-4-bromophenyl-3-6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl-4,5-dihydro-1h-pyrazol-1-yl-4-oxobutanoic acid, 5-4-bromophenyl-3-1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl-4,5-dihydro-gamma-oxo-1h-pyrazole-1-butanoic acid
PubChem CID 44657732
IUPAC Name 4-[(3E)-5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenylquinolin-3-ylidene)pyrazolidin-1-yl]-4-oxobutanoic acid
SMILES CC1=CC2=C(C(=C3CC(N(N3)C(=O)CCC(=O)O)C4=CC=C(C=C4)Br)C(=O)N=C2C=C1)C5=CC=CC=C5

Specifications

Quantity 50 mg
Formula Weight 558.42
Percent Purity >97%
Chemical Name or Material DQP 1105

Safety and Handling

Recommended Storage Store at -20°C
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