Tocris™ E 64

Potent and irreversible cysteine protease inhibitor

Manufacturer: Tocris™ 5208/50

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Catalog No. 52-085-0

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For Research Use Only


    Product Type E 64
    Inhibitors E 64
    Purity >98
    Molecular Weight 357.41
    Quantity 50mg

    Potent and irreversible cysteine protease inhibitor (IC50 values are 1.4, 2.5 and 4.1nM for cathepsin K, L and S respectively. Also inhibits papain, calpain, cathepsin B and cathepsin H. Has no effect on serine proteases. Reduces HSC-3 tongue cancer cell invasion and induces oxidative stress and apoptosis in filarial parasites. Also inhibits autophagy-associated lysosomal degradation in vitro.

    • Chemical Name: (2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid
    • Formula: C15H27N5O5
    • CAS Number: 66701-25-5
    • Solubility: Soluble to 20mM in water
    • Purity: >98

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