Invitrogen™ EFHD2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578575

Catalog No. PIPA578575

Description

Positive Control: H1299, HeLaS3, mouse brain, rat brain Predicted Reactivity: Rhesus Monkey (100%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLC-gamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-kappa-B-activating branch.

Specifications

• Antigen: EFHD2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Efhd2
• Gene Alias: 2600015J22Rik; AA408606; D4Wsu27e; EF hand domain containing 2; EF hand domain family, member D2; EF-hand domain family member D2; EF-hand domain family, member D2; EF-hand domain-containing protein D2; Efhd2; MGC4342; RP3-467K16.3; swiprosin 1; swiprosin-1; Sws1; testicular tissue protein Li 62
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27984, 298609, 79180
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q4FZY0, Q96C19, Q9D8Y0
• Gene Symbols: Efhd2
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EFHD2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov