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EGFR Antibody (DH8.3) - EGFRvIII, Mutant - BSA Free, Novus Biologicals™
SDP

Catalog No. N2505990025 Shop All R&D Systems Products
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N2505990025 0.025 mL
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Catalog No. N2505990025 Supplier Novus Biologicals Supplier No. NBP2505990.025ML
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Description

Mouse Monoclonal Antibody has been used in 5 publications

EGFR Monoclonal specifically detects EGFR in Human samples. It is validated for Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, CyTOF-ready.

Specifications

Antigen EGFR
Applications Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, CyTOF
Classification Monoclonal
Clone DH8.3
Concentration 1 mg/mL
Conjugate Unconjugated
Dilution Western Blot 1:100 - 1:2000, Flow Cytometry 1:10 - 1:1000, ELISA 1:100 - 1:2000, Immunohistochemistry 1:10 - 1:500, Immunoprecipitation 1:10 - 1:500, CyTOF-ready
Formulation PBS with 0.02% sodium azide
Gene Accession No. Q01279
Gene Alias avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGFR variant III, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ERBB, ErbB1, ERBB1PIG61, HER1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Gene Symbols EGFR
Host Species Mouse
Immunogen Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.
Quantity 0.025 mL
Primary or Secondary Primary
Gene ID (Entrez) 1956
Test Specificity Clone DH8.3 of EGF R/ErbB1 antibody is specific for Truncated EGFR which is also called EGFR type III, EGFRvIII or delta-EGFR (characterized by a deletion of 267 amino acids in the extracellular domain, leading to a receptor which is unable to bind ligand yet is constitutively active). Because of its impaired internalisation and degradation, EGFRvIII is known to enhance tumourigenesis. NOTE: Clone DH8.3 DOES NOT cross-react with full length or wildtype EGFR (wtEGFR).
Target Species Human
Content And Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Isotype IgG1
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