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EGFR Antibody (DH8.3), PE/Cy7 - Mutant, Novus Biologicals™
SDP

Catalog No. N250599PEC7 Shop All R&D Systems Products
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Catalog No. N250599PEC7 Supplier Novus Biologicals Supplier No. NBP250599PECY7
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Description

Mouse Monoclonal Antibody

EGFR Monoclonal specifically detects EGFR in Human samples. It is validated for Flow Cytometry.

Specifications

Antigen EGFR
Applications Flow Cytometry
Classification Monoclonal
Clone DH8.3
Conjugate PE-Cyanine7
Dilution Flow Cytometry
Formulation PBS with 0.05% Sodium Azide
Gene Alias avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ERBB, ErbB1, ERBB1PIG61, HER1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Gene Symbols EGFR
Host Species Mouse
Immunogen Synthetic peptide corresponding to the junctional region of the truncated receptor LEEKKGNYVVTDHC,conjugated to keyhole limpet haemcyanin.
Purification Method Protein G purified
Quantity 0.1 mL
Research Discipline Cancer, Cell Biology, Cell Cycle and Replication, Cellular Markers, Cellular Signaling, Growth and Development, Hypoxia, Phospho Specific, Signal Transduction, Tumor Suppressors, Tyrosine Kinases
Primary or Secondary Primary
Gene ID (Entrez) 1956.0
Test Specificity Clone DH8.3 of EGF R/ErbB1 antibody is specific for Truncated EGFR which is also called EGFR type III, EGFRvIII or delta-EGFR (characterized by a deletion of 267 amino acids in the extracellular domain, leading to a receptor which is unable to bind ligand yet is constitutively active). Because of its impaired internalisation and degradation, EGFRvIII is known to enhance tumourigenesis. NOTE: Clone DH8.3 DOES NOT cross-react with full length or wildtype EGFR (wtEGFR).
Target Species Human
Content And Storage Store at 4°C in the dark. Do not freeze.
Isotype IgG1
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